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Abstract Acknowledgement I wonld like to take this opportunity to express my deep thanks and gratitude to my teacher and advisor, Professor Dr. Mahmoud Essawy, Professor of Pediatrics, Faculty of Medicine, Ain-Shams University, for his considerable support and help, and his continuous guidance. It has been my good fortune to work under his supervision. My gratitude also goes to Professor Dr. Hussein ElDamasy, Professor of Medicine and Endocrinology, Faculty of Medicine, Ain-Shams University, for his valuable advice and unfailing support, My deepest thanks are also extended to Dr. Mohammed Salah El-Din El-Kholy, Lecturer of Pediatrics, Faculty of Medicine, Ain-Shams University, for encouraging me to proceed with this work, and for his real ~1idance and support. I am greatly indebted to Dr. Galila Mokhtar, Lecturer of Pediatrics, Faculty of Medicine, Ain-Shams University, for her continuous ~idance throughout this work, and for her generous advice and willingness to help. I am really grateful to her. And last, but by no means least, I wish to thank all the biochemists of Ain-Shams University Endocrinology Unit, for their help in the practical part of this |