الفهرس 
Introduction and Aim of the workOnly 14 pages are availabe for public view
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Abstract
Liver diseases lead to damage of liver tissue and hepatic dysfunction. This liver injury requires fast and effective therapeutic modalities to compensate the tissue damage. Therefore, considerable attention has been directed to explore novel therapeutic approaches including the use of safe hormones that have promising role to promote and accelerate tissue regeneration.
The present work aimed mainly to:
(1) Investigate the efficacy of safe hormones such as melatonin and DHEA for their promising properties on liver regeneration and revascularizations in partially hepatectomized and early stage of liver cirrhosis of rats.
(2) Evaluating the effectiveness of each selected treatment on rats through assessment of liver function tests, biochemical markers of liver regeneration, such as growth factors and cytokines in addition to enzymatic and non-enzymatic antioxidants, nitric oxide and lipid peroxide using spectrophotometric and ELISA methods.
(3) Histopathological examination of liver in normal and different therapeutic treated groups.
To achieve this, early stage of cirrhosis and partial hepatectomy were induced experimentally in rats followed by determination of the following parameters:
-In serum :liver function tests [aspartate aminotransferase (AST),alanine aminotransferase (ALT) and alkaline phosphatase (ALP)]enzyme activities, total protein, albumin and total bilirubin levels, growth factors and cytokines [hepatocyte growth factor(HGF),epidermal growth factor(EGF) and transforming growth factor-beta (TGF-ß)] and[inteurleukin-1 (IL-1),tumor necrosis factor-α(TNF-α)].
-In hepatic tissue:enzymatic (catalase) and non-enzymatic (glutathione) antioxidants activities,lipid peroxide expressed as malonaldehyde(MDA) and nitric oxide(NO).
In order to correlate the resulted biochemical results with any parallel histological changes, the biochemical study was followed by histopathological assessment.