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Abstract Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia which results from either defect in insulin secretion, insulin action, or both. Chronic hyperglycemia of diabetes mellitus is associated with long term damage, dysfunction, and failure of different organs, especially the eyes, kidneys, nerves, heart and blood vessels. Red cell distribution width is a measure of variation in red cell size in a blood sample. It is calculated by both impedance and flow cytometric analysers as part of the routine full blood count. Mathematically, RDW=(SD of red cell volume/mean cell volume) × 100. Higher RDW values mean a greater variety of cell sizes are present. The normal range for RDW is between 11.5 and 14.5%. Red cell distribution width (RDW) is considered a prognostic marker which may reflect an underlying inflammatory process. This marker can be used as a predictor for macrovascular and microvascular complications of diabetes mellitus. Our goal was to determine if RDW is a marker of inflammation in type 2 diabetes. Our study included two groups: Group I: included 100 patients of type 2 diabetes mellitus with or without micro or macrovascular complications. Group II : which included 25 healthy controls. We found that increase in Red Cell Distribution Width (RDW) in patients with type 2 diabetes mellitus as compared to controls. Keywords: Type 2 diabetes mellitus. Inflammation. Red cell distribution width. Macrovascular comp.of D.M. Microvascular comp. of D.M. |