الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Inflammatory and non inflammatory colitides represent a heterogeneous group of diseases, often difficult to diagnose and classify, whose diagnostic criteria are not always uniform. Unfortunately, apart from infectious form of colitis , no data are available for non-IBD colitides. The term `non-specific colitis’ has been linked in the past to chronic inflammatory bowel disease, and has also been used extensively in daily practice by many pathologists without strict definition. Aim of the work: Study the clinicolaboratory, colonoscopic, histopathological, immunohistochemical and anorectal manometry characteristics of patients with non specific colitis in order to optimize therapy. Patients and Methods: One hundred patients with lower gut symptoms and their colonoscopy was free are selected. Colonic biopsies were taken for histopathology and immunohistochemistry for TNF and IL-2. Anorectal manometry was done to all patients and compared to control. Results: 73% of biopsies showed non specific colitis, 9% showed ulcerative colitis, 12% showed lymphocytic colitis and 8% collagenous colitis. TNF and IL-2 are significantly expressed in patients with non specific colitis relative to control. Anorectal manometry parameters are significantly changed in patients with non specific colitis relative to control.