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Abstract Diarrheal d1seases are a major health pcoblem in the war ld today, such morb1d1ty and mortality results from complications of prolonged mreractable d1arrhea. Although diarrhea ” dlff1cult to def1ne quantnat1vely, mtracrable d1arrhea IS distmguished from the chrome nonspecifiC d1arrhea syndrome by malabsorptiOn, malnu:rnwn and !allure to thnve, most commonly cused by allerg1c (cel1ac sprue, cow’s milk allergy) or mfectwns (postmfectwns enterocolJtis, g1ar d1astsl disease. A s1mdar pathophyswlog1c syndrome often develops, mucosal villous atrophy, crypt pro!Jferation and inilammatwn lead to carbohydrate, fat, and protem malabsorptiOn the resulung d1arrhea may mvolve several mecharusms mcludH1g osmotic and secretory diarrhea, bactena1 overgrowth and diSordered motility, eventually malnutntwn and fadure to thnve may develop into a v<owus cycle w1th failure to heal mucosal damage and further debllitatwn, d1agnosJS of chrome diarrheal dtsease should mclude a caerful dietary history and attension to signs of malnutritiOn. Manageme:ot JS ch1e!ly d1rected at prov1dmg adequat<” nutrtt1on through oral elemental d1e:s or total parenteral nurtton, however long rehabJiltatJOns may be necessary 1f early mtervent1on is not insututed ,prevent1on of the orig1nal causes can be most effect1vely implemented by encouragmg breast feeding. |