الفهرس 
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Abstract
Biochemical and molecular studies of Apolipoproteins B100, A1 and E on controlled and uncontrolled type II diabetic patients in addition to normal healthy controls were done to investigate the relationship of apolipoproteins with the severity of diabetes mellitus and to establish whether Apo B100/Apo A1 ratio can be used as a marker for prediction of CAD in type II DM, as well as, to determine the influence of Apo E genotypes on plasma lipid and lipoprotein concentrations in these Egyptian diabetic patients.This study was carried out in type II diabetic patients attending Alarish Hospital, North Sinai, Egypt.
A total of 60 subjects were selected. 20 healthy non diabetic controls and 40 were diabetic cases, in order to study the effect of uncontrolled diabetes on the lipid profile, lipoprotein levels and some biochemical and molecular studies on apolipoproteins.
All cases included in this study were classified according to their fasting blood glucose level into control group (FBG level less than 107 mg/dl) and diabetic patients (FBG level more than 176 mg/dl). Also, the diabetic patients were further subdivided according to their glycosylated hemoglobin % (HbA1c%) into controlled type II diabetic patients (with HbA1c less than 8 %) and uncontrolled type II diabetic patients (with HbA1c more than 8 %). So, all the studied cases were classified into 3 main groups:
- Group I : Control group (20 healthy individuals)-Group II : Controlled type II diabetic patients group (20 diabetic patients)- Group III : Uncontrolled type II diabetic patients group (20 diabetic patients).