الفهرس 
NORM.AL HEMOSTASISOnly 14 pages are availabe for public view
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Abstract
Anti cardiolipin .:Unibociie5 :A CAs’ are members of the
unique family of antiphospholipid antibodies AP.-\s 1 that alsc
includes the lupm anticoagulant and the reagimc antibody of
treponema] infection.
ACJ~3 have been associated ~~Yith tr_ro~:nboe~bolic eYent::: i:1
riYO. AC_-\s ha·Fe been deseibed iiJ. various li\-er diseases as
and hepatomas. This study conduc:;ed an iwcestigation on AC’\.s
in 60 patients with chronic liver disease of different aetiologies
and different grades of li-\-er dysfuEct.ion v~·ii}1 a~d v.~ithout
bJeeding episodes \Vhethe:r varicea1 or orjficjal.
The results of this study sDoweci :r1E: presence of ACAs n1
2oc·, of the 60 patients studied. All ACAs positi•·e cases were
arnong the combined schist.oson1iasis and hepatitis group.
probab:y due to dysfunction of the immc;.noregulator;:
rnechanisn1s i!1 advanced liYer disease.
There was highly significant difference between ACAs
pcsitiH’ cases and ACAs negatin’ cases regarding serum
album,:. this might pay our attention ·,o the possibility :i1at
AC”-h n•ight cause aggravation of hepatic failure.
:\:ne out cf 12 patient::3 with AC_.\.s shov\·ed thron1bouc
ccm1plicatiom ir. d1fferem forms. Th!s finding migb open up a new world for research and exploration to put a rationale of
therapeutic modalities in such patients.
ACAs have an inhibitory effect on protein C activity. The
results of our study showed that the decrease in protein C
activity was highly significant in ACAs positive cases in
comparison to ACAs negative cases.
The absence of bleeding episodes in ACAs positive cases
whose protein C was severely depressed, might pay our
attention to the possibility of a potential role of ACAs in the
complex and diverse spectrum of hemostatic defects in liver
disease via inhibition of protein C activity. This finding might
provide convincing evidence for a compensatory and protective
mechanism offered by ACAs in order to re-establish the balance
between the coagulation system on one hand and the
anticoagulant and fibrinolytic systems on the other hand.