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Abstract Anti cardiolipin .:Unibociie5 :A CAs’ are members of the unique family of antiphospholipid antibodies AP.-\s 1 that alsc includes the lupm anticoagulant and the reagimc antibody of treponema] infection. ACJ~3 have been associated ~~Yith tr_ro~:nboe~bolic eYent::: i:1 riYO. AC_-\s ha·Fe been deseibed iiJ. various li\-er diseases as and hepatomas. This study conduc:;ed an iwcestigation on AC’\.s in 60 patients with chronic liver disease of different aetiologies and different grades of li-\-er dysfuEct.ion v~·ii}1 a~d v.~ithout bJeeding episodes \Vhethe:r varicea1 or orjficjal. The results of this study sDoweci :r1E: presence of ACAs n1 2oc·, of the 60 patients studied. All ACAs positi•·e cases were arnong the combined schist.oson1iasis and hepatitis group. probab:y due to dysfunction of the immc;.noregulator;: rnechanisn1s i!1 advanced liYer disease. There was highly significant difference between ACAs pcsitiH’ cases and ACAs negatin’ cases regarding serum album,:. this might pay our attention ·,o the possibility :i1at AC”-h n•ight cause aggravation of hepatic failure. :\:ne out cf 12 patient::3 with AC_.\.s shov\·ed thron1bouc ccm1plicatiom ir. d1fferem forms. Th!s finding migb open up a new world for research and exploration to put a rationale of therapeutic modalities in such patients. ACAs have an inhibitory effect on protein C activity. The results of our study showed that the decrease in protein C activity was highly significant in ACAs positive cases in comparison to ACAs negative cases. The absence of bleeding episodes in ACAs positive cases whose protein C was severely depressed, might pay our attention to the possibility of a potential role of ACAs in the complex and diverse spectrum of hemostatic defects in liver disease via inhibition of protein C activity. This finding might provide convincing evidence for a compensatory and protective mechanism offered by ACAs in order to re-establish the balance between the coagulation system on one hand and the anticoagulant and fibrinolytic systems on the other hand. |