الفهرس | Only 14 pages are availabe for public view |
Abstract COPD is the fourth leading cause of death in the world and further increase in its prevalence and mortality can be predicted in the coming decades . COPD is characterized by airflow limitation that is not fully reversible. The airflow limitation is usually progressive and associated with an abnormal inflammatory response of the lung to noxious particles or gases. AECOPD is associated with increased risk of short-term mortality and impaired respiratory health status. Exacerbations are also costly, making prevention of it an important goal of COPD management. Vitamin D is produced by the skin after exposure to UVB, underwent 2 steps hydroxylation to become in active form which has skeletal and extra skeletal function. Vitamin D deficiency has been associated with lower lung function and higher prevalence of infections. The study were carried on 75 subjects: 25 COPD patients in AECOPD , 25 patients with stable COPD and 25 normal healthy controls. A written informed consent were taken from all subjects before enrollment in the study. All the included subjects were subjected to the following: • Complete history taking. • Complete physical examination. • Laboratory investigations: CBC, ESR, CRP, RBS, liver and kidney function tests. • Plain chest X-ray PA and lateral views and chest CT when needed. • ECG and echocardiography. 104 summary • Pulmonary function tests: FEV1and FVC were measured with standard spirometric techniques and bronchodilator reversibility testing. • Assessment of serum levels of 25 (OH) vitamin D were performed with a commercially available ELISA kit. Results showed that: • There was a significant statistical difference among the three groups as regards the serum 25(OH)VD level that became lower in AECOPD group and higher in control group and in stable COPD group, it was in between. • There was a statistical significant positive correlation between serum levels of 25(OH)VD and FEV1 and PaO2, but 25(OH)VD correlate inversely with BMI and PaCO2. |