الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 49 |  |  |
| | | from | 49 | | |
Abstract
COPD is the fourth leading cause of death in the world and further
increase in its prevalence and mortality can be predicted in the coming
decades . COPD is characterized by airflow limitation that is not fully
reversible. The airflow limitation is usually progressive and associated
with an abnormal inflammatory response of the lung to noxious particles
or gases. AECOPD is associated with increased risk of short-term
mortality and impaired respiratory health status. Exacerbations are also
costly, making prevention of it an important goal of COPD management.
Vitamin D is produced by the skin after exposure to UVB,
underwent 2 steps hydroxylation to become in active form which has
skeletal and extra skeletal function. Vitamin D deficiency has been
associated with lower lung function and higher prevalence of infections.
The study were carried on 75 subjects: 25 COPD patients in
AECOPD , 25 patients with stable COPD and 25 normal healthy controls.
A written informed consent were taken from all subjects before
enrollment in the study.
All the included subjects were subjected to the following:
• Complete history taking.
• Complete physical examination.
• Laboratory investigations: CBC, ESR, CRP, RBS, liver and kidney
function tests.
• Plain chest X-ray PA and lateral views and chest CT when needed.
• ECG and echocardiography.
104
summary
• Pulmonary function tests: FEV1and FVC were measured with
standard spirometric techniques and bronchodilator reversibility
testing.
• Assessment of serum levels of 25 (OH) vitamin D were performed
with a commercially available ELISA kit.
Results showed that:
• There was a significant statistical difference among the three
groups as regards the serum 25(OH)VD level that became lower in
AECOPD group and higher in control group and in stable COPD
group, it was in between.
• There was a statistical significant positive correlation between
serum levels of 25(OH)VD and FEV1 and PaO2, but 25(OH)VD
correlate inversely with BMI and PaCO2.