الفهرس | Only 14 pages are availabe for public view |
Abstract Introduction and Aim of the Work There arc rich interactions between the thyroid gland and the liver. TI1e liver contributes significantly to the thyroid economy through its control of hormone metabolism. The liver is intimately involved in thyroid physiology via conversion of tetra-iodothyronine (T4) to tri-iodothyronine (T3), conjugation and biliary excretion of thyroid hormones and as the major production site of the thyroid binding globulin affecting the concentration of these hormones in blood. On the other hand , hyperthyroidism and hypothyroidism can present with hepatic manifestations. Hyperthyroidism may be associated with elevation of alanine aminotransferase and alkaline phosphatase. which is mainly of bone origin. Hypothyroidism may be a’sociated with elevation of aspartate aminotransferase (Fong et a] . 1992). Jaundice may occur in hyperthyroidism (Thompson et a! . 1994 ). Finally . in a number of viral and autoimmune disorders both the liver and thyroid are affected simultaneously (Salata et a] . 1985) . and thyroid dysfunction is among the most commonly encountered immunological disorders in patients 11 ith autoimmune hepatitis (Krawitt et al. jl)l)(l J. The aim of the present study was to study thyroid size and function in Egyptian patients with common chronic liver di:-cases. |