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Abstract Coronary bifurcations are frequently encountered and approximately 15% to 20% of percutaneous coronary interventions (PCI) are performed to treat bifurcations. PCI for bifurcation disease has been considered technically challenging and historically been associated with worse clinical outcomes than non bifurcation lesions. The side-branch (SB) is emerging as critical point, accounting for more than a third of the significant restenosis in the DES era. A series of data supports the adoption of a conservative strategy: stenting the main vessel (MV) only and reserving a conservative approach on the SB. Yet, the clinical relevance in terms of inducible ischemia of sub-optimal angiographic result has not been clarified. The aim of the study was to evaluate the immediate and long term outcomes of PCI of bifurcation lesions with single DES in terms of evaluation of side branch management, and evaluation of the behavior of different types of drug eluting stents in such lesions. The study design was retrospective and prospective study of patients with bifurcation lesions treated with single DES strategy. All patients were subjected to revision of all demographic data; age, risk factors history (family history, hypertension, diabetes mellitus, dyslipidemia, and smoking), previous MI, previous PCI, CABG, CVS and PAD. PCI procedural details included; Culprit vessel, site of the lesion, type of the bifurcation lesion according to Medina classification, type of guiding catheters, type of guide wires, Balloon predilatation (either main vessel or side branch), type of stent and deployment pressure, direct stenting of the main branch, and post dilatation (either main vessel or side branch).In addition to the angiographic outcomes as regards; TIMI III flow in main branch ,TIMI III flow in the side branch, and ostium of side branch. Patients were followed up for a minimum of one year outcome regarding the major adverse cardiac events (death, MI, TVR, ISR, TLR, non TLR). In this study, the following results were found among 76 patients: • In hospital outcome: there was a case (1.3%) of subacute stent thrombosis with Cypher select plus stent where neither balloon dilatation nor final kissing balloons were done. • At follow up: a patient (1.3%) with Taxus Liberte had in-stent restenosis where pre-balloon dilatation followed by final kissing balloons were done.•Also at follow up, there was one case (1.3%) of cardiac death with Promus element stent were neither balloon dilatation nor final kissing balloons were done. |