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Abstract INTRODUCTION Caffeine and nicotine are worldwide known socially accepted drugs in most countries. Due to their being addictive when they are ingested or inhaled, societies from developed countries found it necessary to control their use and availability to a certain extent. This was generally attained through advertisement for example or through production of products with attenuated nicotine or caffeine content. Nevertheless, their being used on a daily basis without prescription to increase the sense of well-being and mood-altering contributes to their hazardous effects. Caffeine is a CNS stimulant that is used in an abused manner. It acts through the inhibition of the enzyme phosphodiesterase resutling in higher levels of cAMP. Nicotine is a cholinomimetic drug that activates parasympathetic nervous system through release of acetylcholine that can interact with receptors on sympathetic nerves inhibiting the release of norepinephrine. Nicotine is present in cigarretes and as a constituent of insecticides where acute nicotine poisoning may occur during spraying. Cigarette smokers are usually coffee drinkers. Through the great zest initiated in man to both drugs, acquired tolerance might develop leading to drug dependence. Eventually habituation and psychological dependence i.e. psychic craving, are indorsed. This is usually the case widely spread among young adult individuals to overcome emotional distress . . I . |