الفهرس 
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Abstract
Zinc i.~ an es,~ential trocf’ metal that is directly involved in
the physiology of i~ulin. There are ~evera/ reasons to suspect
that abnormal zinc metabolism could play a role in the pathogenesis
of diabete.~ mellitus. and some of its complications (Kinlaw et
al., l983).
Insulin is stored in the pancreatic beta-cell as a hexameric
crystal containing a variable number of zinc molecules (Scott and
Fisher, l938). This crystal is released into the portal venous system
at the time of beta-cell degranulation. Variation of the zinc-toinsulin
ratio within this crystal has been shown to alter its antigenic
properties (Arquilla et al., l978b).
In addition to its structural role in the storage form of insulin,
zinc is also capable of modulating insulin action. Arquilla et al.
(l978a), demonstrated that hepatic binding of insulin is enhanced
by zinc.
Stimulation o( Upogene8is in the adipocyte ha.<> aim been described,
with synergism between insulin and zinc (Coulston and Dandonna,
1980).
Aim of this studY is to in\’estigate :inc deficiency in type
11 diabetes mt!l/itJ.J.::, ana to .”’uggest a hypothesis regarding its mechanism