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Abstract 1- INTRODUCTION The challenge of pests to humans during the last 30 years led to the introduction of different group~ of pesticides into the environment. The fact that the resistance of insects to pesticides arose by recurrent treatment of insects throughout several generations by the same insecticide is well acknowledged. This led to the introduction of more effective pesticides in plant protection programs and ag~istman natural enemies. Subsequently more poisonous insecticides have been introduced into the environment. The widespread use and sometimes the abuse of pesticides and other agrochemicals in agriculture in Egypt, might be posing a threat to the differ•nt biological systems including humans~ plants and animals. Sine• it is now well established that most of the mutagens proved to be also carcinogens it is therefore, worthwhile to care about the genetic hazards of pesticides and comparing the anticipated mutagenic potentialities. In ather words, determin1ng whether a proper chemical can cause an abrupt heritable change in the composition or arrangement of genes. It is evident that same pesticides can induce gene mutations and chromosomal similar to mutagenic agents <Garrett et al., 1986). aberrations In spite of that, pesticides are still widely used and many neN forms of the different groups Ci.e. organophosphorus, pyrethroid, benzocy~zol, carbamates and chlorinated hydrocarbons) are ~nnu~lly producwd. This can be attributed to the fact that the applic~tion of pesticides is still the most economical effective way for controlling plant pest•. Although the trend toward the ~afar use of pesticide~ and concern for public health beg•n in the twenties of this century, but the interest in the anticipated mutagenic potentialities of pasticides grown up actually during the last two decades. The mode of action and subsequently the specificity of each |