الفهرس | Only 14 pages are availabe for public view |
Abstract his study included 66 patients with locally advancedbreast cancer not operated and did not receive any prior chemotherapy, radiotherapy or hormonal treatment referred to El-salam oncology center from April 2010 through October 2012. Patients were randomly allocated into 2 groups, each consisting of 33 patients: Group (A) patientsreceived 4 cycles of FEC regimen (5-fluorouracil 500 mg/m2, epirubicin 100 mg/m2, cyclophosphamide 500 mg/m2) each repeated every 21 days. Group (B): patients received 4 cycles of epirubicin 60 mg/m2, docetaxel 75 mg/m2each repeated also every 21 days. The two treatment group were comparable as regards of patient characteristics such as age, performance, tumor grade, histopathology, tumor size, axillary lymph node status, hormonal status (ER - PR). Treatment regimens in the two groups were tolerable with no treatment related mortality. There was no significant difference as regard treatment related toxicity between the two treatment groups. The 2 years disease free survival for group A and B was statistically significant P value 0.017. The 2 years overall survival was statistically insignificant P value 0.064. T Summary 143 There was no statistically significant difference regarding Distribution of the sites of distant metastases p value 0.815. The response of treatment was mainlyto ERand/ orPR -ve and Her- 2 neu -ve in both groups withno statistically significant difference. Multi-regression analysis shows that both LN (1-3) with T-Size (T3) are the most sensitive predictors for increased DFS (p<0.01). Multi-regression analysis shows that PCR with Hormonal status (ER&/PR -ve) & (Her 2 neu –ve), in addition to performance status (0 & 1) are the most sensitive predictors for increased OS (p<0.01). In conclusion the addition of non cross resistance agent (Docetaxel) to Epirubcin showed statistically significant difference in 2 years DFS and no statistically significant difference regarding 2 years OS. There was no statistically significant difference as regards toxicity which was tolerable for the two regimens. Although the previous findings were recorded, but still this study lacks the adequate number of patients and needs a longer time of follow up. |