الفهرس 
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Abstract
Background .C-Reactive Protein (CRP), an acute phase reactant has long been considered as a classic marker of inflammation. Ageing is characterized by a chronic, low-grade inflammatory status, the so-called “inflame-ageing”,. Diabetes is also associated with low-grade inflammation .The normal process of reproductive ageing is characterized by marked hormonal changes. During the menopause, estradiol (E2) levels decrease dramatically, whereas testosterone levels present a small decline or remain unchanged. Objective .The aim of this study was to assess serum levels of endogenous sex hormones (estrogen and testosterone) as well as high sensitive C -Reactive protein (hs-CRP), a serum marker of inflammation in elderly women with and without type 2 diabetes.
Research Design. This study was done in the period between august 2009 to august 2011, The study population included a total number of 60 post menopausal elderly females, 20 healthy non diabetic elderly females as control group and 40 diabetic females. The diabetic females were divided into two groups according to presence or absence of complications cardiovascular diseaes (CVD) into two groups,complicated group and non complicated group. It was also divided into two groups according to glycosylated hemoglobin (HbA1c) to controlled group and non controlled group.
Methods. Total testosterone, total estradiol, hs-CRP and HbA1c were measured in diabetic and non diabetic elderly women.
Results. As regard hs-CRP there was a high significant difference between patients(2,2±,56 mg/L) and control group(1.60 0.39 mg/L) and also there was a significant difference between complicated(2.160.51 mg/L) and non complicated group(2.080.76 mg/L) and no significant difference in controlled and non controlled group . As regard the serum estradiol, there was a high significant difference between patients (22.513.9 pg/ml) and control group (12.92.71 pg/ml) and non significant difference as regard complicated and non complicated and also in controlled and non controlled group. As regard the serum testosterone, there was no significant difference between patients and control group, complicated and non complicated group and controlled and non controlled group.
Conclusion. In type 2 diabetic postmenopausal elderly women there was significant association between inflammation and serum estradiol while there was no association between inflammation and serum testosterone. In type 2 diabetic patients complicated with cardiovascular diseaes( CVD )neither of two hormones was associated with inflammation. Also no association was observed as regard the two hormones , inflammation and control of diabetes .Keywords: Sex hormones, Postmenopausal women, Inflammation, Elderly, Diabetes Contents.