الفهرس 
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Abstract
The original work of the present thesis is to synthesize
some new pyrazolo[3,4-d]pyrimidine derivatives and study
some of their reactions. Since pyrazolo[3,4-d]pyrimidine
derivatives have received a great attention due to their
versatile pharmacological activities, so, some of the prepared
compounds were tested for their antitumor and antioxidant
activities.
Thus, when 4-chloro-1-(9-methyl-5,6-dihydronaphtho-
[1’,2’:4,5]thieno[2,3-d]pyrimidin-11-yl)-1H-pyrazolo[3,4-d]-
pyrimidine (3) was treated with different primary or
secondary cyclic amines (hydrazine hydrate, ethylamine,
phenylethylamine, benzylamine, glucosamine hydrochloride,
glycine, phenylhydrazine, ethylenediamine, piperidine,
cyclohexylamine, morpholine or piperazine), the reaction
afforded the corresponding 4-substituted aminopyrazolo[3,4-
d]pyrimidines 4-15 (Scheme 1).