الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
There is a rise in a number of patients with diabetic nephropathy (DN) in patients with type 1 and type 2 diabetes mellitus. Adiponectin is a cytokine that has antiproteinuric and nephroprotective effects in diabetic and nondiabetic chronic kidney disease. So, the present study aimed to study the value of adiponectin in diabetic nephropathy patients, its relationship to progression of the disease. To render this aim achieved, we recruited 70 diabetic patients in addition to 20 age and gender matched controls. They were subjected to careful history taking, thorough clinical examination and laboratory examination including serum adiponectin levels. The diabetic group was subsequently equally divided into three groups: normoalbuminuric, microalbuminuric and macroalbuminuric groups. In the present study, comparison between patients and controls regarding the demographic and laboratory data had shown that diabetic patients had significantly higher levels of serum creatinine, total cholesterol, triglycerides, HbA1c, FBS and PPBS when compared with controls. Also, they had significantly lower hemoglobin and albumin levels when compared with their healthy counterparts. In the present study, comparison between patients and controls regarding serum adiponectin levels had shown that diabetic patients with normal urinary albumin had significantly lower adiponectin levels when compared with controls. Comparison between patients with normal urinary albumin, microalbuminuric patients and macroalbuminuric groups had shown statistically significant higher levels of adiponectin in the later group. In the current study, there was a steady increase in the creatinine and albumin/creatinine ratio levels with worsening of albuminuria. The utility of adiponectin in prediction of diabetic nephropathy showed best results in differentiating patients with macroalbuminuria from patients with normal urinary albumin.