الفهرس 
Liver disordersOnly 14 pages are availabe for public view
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Abstract
Hepatocellular carcinoma (HCC) is one of the most deadly cancers worldwide and it represents a major world health problem. The burden of hepatocellular carcinoma (HCC) has been increasing in Egypt with a doubling in the incidence rate in the past 10 years. The genetic alterations that take place in the transformation of normal cells to neoplastic cells give an insight into the molecular mechanism of the disease.
Because of the high prevalence of hepatocellular carcinoma (HCC) in Egypt, new markers with better diagnostic performance than alpha-feto protein (AFP) are needed to help in early diagnosis.Glypican-3 (GPC-3) is a protein that plays a role in the control of cell division and growth regulation. It acts as a tumor suppressor gene in some tissues, while acting as an oncofetal protein in other tissues.
The aim of this work was the study gene expression of GPC-3 in HCC patients in Egypt, and correlates the expression of GPC-3 with clinical pathological data.
In this study, HCC tumor tissue and non-tumor tissue from the same patient were analyzed for the expression of GPC-3.
This study showed that GPC-3 has a significant predictive value in diagnosis of HCC with high specificity and sensitivity and it is more related to the severity of tumor grade than AFP, and statistically no significant correlation between AFP and GPC-3.
So, GPC-3 may serve as a potential marker for the diagnosis of HCC.
Keywords: HCC, riskfactors, tumor markers, glypican-3.