الفهرس 
Anatomy of the pancreasOnly 14 pages are availabe for public view
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Abstract
Acute pancreatitis is the most common complication of diagnostic and therapeutic endoscopic retrograde cholangiopancreatography. Several clinical trials used GTN to prevent the incidence of PEP. However, the results were still controversial. This study aims to conduct a meta-analysis of published, full-length, randomized controlled trials evaluating the effect of prophylactic GTN on the prevention of PEP and the prevention of hyperamylasemia. Literature searches were conducted using PubMed, EMBASE, The Cochrane Library and Web of Knowledge databases, using keywords ”post-ERCP” and ”pancreatitis” and limited in randomized controlled trials.
Eleven RCTs involving 2395 patients were included. Eleven RCTs compared GTN with placebo for PEP prevention. Meta-analysis showed the overall incidence of PEP was significantly reduced by GTN treatment (OR 0.65; 95% CI, 0.483-0.874). Nevertheless, GTN administration did not decrease the incidence of moderate to severe PEP (OR 0.687; CI, 0.407-1.16). Subgroup analyses revealed that GTN administered by sublingual was more effective than transdermal and topical in reducing the incidence of PEP. Additionally, the incidence of hyperamylasemia was significantly reduced by GTN treatment (OR 0.483; 95% CI, 0.289–0.809). In conclusion, this meta-analysis show that the prophylactic use of GTN have an effective and relative safe intervention for preventing PEP and hyperamylasemia, but show no effect of the severity of PEP.