الفهرس 
Introduction and aim of the work
Chapter 1: Hepatitis C virusOnly 14 pages are availabe for public view
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Abstract
The current retrospective, case- control, hospital based study was carried out in the Internal Medicine Department, El-Minia University Hospital along the period between August 2012 and September 2013.
This study aimed to identify whether gene polymorphisms of chemokine receptors; CCR2-64Ile, CCR5-∆32, CCR5-59029 and CCR6-rs2301436 have a role in disease outcome and therapeutic response of antiviral drugs in Egyptian patients with CHC infection. Also the role of these gene polymorphisms in susceptibility and clinico-pathological features of HCC in HCV-related Egyptian cirrhotics compared with a group of apparently healthy volunteers and the group of CHC patients was studied as well.The current study revealed that the group of CHC patients and healthy controls were comparable as regards age, gender, BMI, WHR, hemoglobin level, platelet count, serum albumin, LDL-C, FSG and proportion of diabetics. However, CHC patients had statistically significant higher prevalence of rural residence and smoking and higher values of pretreatment serum AST and ALT, serum HDL-C, fasting serum insulin and HOMA-IR whereas, they had lower values of serum TC and TGs compared with controls.
CHC patients had statistically higher prevalence of heterozygotes and homozygotes of both CCR2-64Ile and CCR5-∆32 allelic variants. Also 64Ile and Δ32 mutant alleles were higher in CHC patients compared with controls. However, the genotypic frequencies and allelic distributions of CCR5-59029 and CCR6-rs2301436 gene polymorphisms did not differ in both groups.