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العنوان
Synthesis and Antimicrobial Evaluation of Quinoxalinone Nucleoside Derivatives /
المؤلف
Atieha, Rimaa Talaat Abd El-Kader.
هيئة الاعداد
باحث / رماء طلعت عبد القادر عطيه
مشرف / أ. د / أحمد حسين مصطفى
مشرف / د/ سعيد علي سعيد
مشرف / د/ حسن عبد الفتاح السيد
الموضوع
Organic chemistry. Nucleosides.
تاريخ النشر
2014.
عدد الصفحات
182 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
Organic Chemistry
تاريخ الإجازة
1/1/2014
مكان الإجازة
جامعة الزقازيق - كلية العلوم - الكيمياء
الفهرس
Only 14 pages are availabe for public view

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Abstract

Several 0- and S-quinoxalineglycosides ha ve been prepared by glycosidation of 3-methyl-2-oxo(thioxo)-1,2-dihydroquinoxaline Ja,b with a-D- glucopyranosyl, a-D-galactopyranosyl and a-D-lactosyl bromide in presence of K2C03follov.ed bydeacetylation with Et3NIH2o. Furthermore, alkylation ofJa,b with 4-bromobutyl acetate, 2-acetoxyethoxymethyl bromide and 3-chloropropanol afforded the corresponding 0- and S-acycJoquinoxaline nucJeosides. The structure of the new
synthesized compounds was confirmed by using IR, IFf, J3C NMR spectra and microanalysis. Some of these synthesized compounds were screened in vitro for antitumor and antimicrobial activity.