الفهرس 
Acknowledgement
Modification of 4-quinolones at positions 3 and 4Only 14 pages are availabe for public view
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Abstract
2-Bromo-4-fluoroaniline (1) was condensed with ethyl 2-cyano-3-ethoxyacrylate (2) in ethanol to afford 3,
which upon refluxing in paraffin oil at 250°C gave 8-bromo-3-cyano-6-fluoroquinoline-4(1H)-one (4).
Then, compound 4 was taken as a versatile building block that allows the synthesis of thieno[3,2-c]-
quinoline, pyrrolo[3,2-c]quinoline, and N-methylpyrrolo[3,2-c]quinoline systems. The newly synthesized
compounds and their derivatives were characterized by elemental analysis and spectroscopy (IR,
1H NMR, 13C NMR, and mass). Furthermore, some of these synthesized compounds were screened for
their biological activities against various pathogenic bacterial and fungal strains. Our results
demonstrate that most of the synthesized compounds possess a significant broad antibacterial activity
against all strains of both gram-positive and gram-negative bacteria. In addition, compound 5 showed
remarkable antifungal activity.