الفهرس 
Introduction
Diabetes MellitusOnly 14 pages are availabe for public view
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Abstract
Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction and failure of different organs especially the eyes, kidneys, nerves, heart and blood vessels. More than 75% of diabetic patients die of vascular complications associated with the disease.
The present study aimed to explore the level of platelets microparticles in children and adolescents with type 1 diabetic patients and its relation to inflammation, glycemic control and microvascular complications.
This study was carried out on 60 children and adolescents with type 1 diabetes mellitus attending the Pediatric Diabetes Clinic, Pediatric Hospital, Ain Shams University. Another group of 40 age- and sex-matched healthy individuals with no obvious medical disorders and not receiving any medication were enrolled as a control group.
All included patients were subjected to detailed medical history (age of onset of diabetes, diabetes duration, insulin therapy, acute metabolic complications: symptomatic hypoglycemic attacks or episodes of diabetic ketoacidosis and chronic microvascular complications: retinopathy, nephropathy and neuropathy, thorough clinical examination and routine work up including; FBS, serum creatinine, total cholesterol, triglycerides, mean HbA1c%, UACR and hs- CRP. Evaluation of platelet microparticles (PMPs) was done by flow cytometric analysis. The studied diabetic patients were subdivided into 2 groups: patients with and without micro-vascular complications.
As regard laboratory data PMPs levels were significantly elevated in all diabetic patients compared with controls. PMPs levels were significantly increased in patients with micro-vascular complications (3.46 ± 1.11%) and non-complicated patients (2.37 ± 1.28%) compared with healthy control group (1.28 ± 0.64%) with highest levels found in patients with complications (p<0.001). PMPs levels were significantly increased in relation to nephropathy (microalbuminuria) Although PMPs were increased in patients with peripheral neuropathy than those without, the difference did not reach a significant level (p>0.05).Correlation studies showed significant positive correlations between PMPs levels and BMI, HbA1c, serum creatinine, total cholesterol, UACR and hs-CRP (p<0.05). Multiregression linear analysis showed that HbA1c, UACR, hs-CRP and total cholesterol were independently related to PMPs levels in type 1 diabetic patients. ROC curve analysis revealed that the cutoff value of PMPs at 2.48% could differentiate patients with and without micro-vascular complications with a sensitivity of 80% and specificity of 73.3%