![]() | Only 14 pages are availabe for public view |
Abstract Colorectal cancer is the third leading cause of cancer worldwide and recurrence of colorectal cancer occurs in about one-third of patients within the first 2 years after surgery. Farly detection of recurrent colorecral carcinoma has become more important as the treatment options for localized disease have improved significantly. Positron emission tomography (PET) for tumor staging and therapy control has been introduced. Rather than anatornic information, it provides physiologic information on glucose uptake and metabolism. The major advantage of Pl~T/CT is that both metabolic and anatornic information for the same body region are obtained at nearly the same time. ’It facilitates the separation of normal physiologic uptake Irorn pathologic uptake, provides accurate localization or functional abnormalities and reduces the incidence of false-positive and false-negative imaging studies. There are different methods for assessment of radiotracer uptake by normal and pathologic tissues, such as visual inspection & the standardized uptake value (SlJV). SUV is a simplified index or I gr-FDG uptake and provides a relative indication or the degree of metabolism within the lesion being evaluated. PET/eT can be used in detection of recurrence of colorecral cancer, as early detection of the disease with frequent follow-up is believed to have an important effect on outcome as early therapy is more effective than delayed therapy. 11 also-can detect lesions that are usually overlooked in C’T such as FDG-avid normal-sized lymph nodes (usually <1 cm) & peritoneal lesions, it also has importance in adding additional findings to inconclusive C’l’ finding. It is extremely useful for therapy response assessment due to its capacity to help distinguishing between residual meiabolically active tumor and areas. |