الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Acinetobcater spp. has emerged as an important nosocomial pathogen that is often MDR and associated with life-threatening infections. Acinetobcater baumannii , a clinically important spp. has tendency toward cross-transmission, particularly in ICUs. It can be associated with pneumonia, skin infections, UTIs, peritonitis, meningitis, and often bacteremia. The present study aimed to detect incidence of Acinetobcater infection in ICUs of El – Menofia Hospital, its demographic features, speciation and antibiotic sensitivity pattern. The study was enrolled during a period of 2 years from 2012 to 2014. The study involved 300 inpatients in ICU Atotal of 300 specimen were collected 144 rectal swabs, 71 swabs from wounds 57 swabs from trachial aspirate, 28 sputum swabs. 100 samples from patients showed growth of Acinetobcater baumannii the other 200 samples , showed no growth of Acinetobcater baumannii all samples were subjected to Culture on chrom agar, further identified by API & disc diffusion method. The predominant type of infection were digestive tract 57% followed by wound infection 24% and respiratory infection 19%. In this study 100 patient were found to be infected with Acinetobcater baumannii. The age means was ( 60.95 ± 10.38 ), a higher incidence in male (69%) than in female (31%) was noticed. In the current study it was found that prolonged stay in ICU,mechanical ventilation,urinary catheterization and hepatic failure were signifcanty associated with Acinetobcater baumannii infecteions. In the present study the antimicrobial susceptibility patterns showed that all the A.baumannii isolates were MDR .All isolates were imipenem resistant and were also totally resistant to ampicillin/sulbactam, ceftazidime,cfteriaxone, ciprofloxacin and piperacillin/tazobactam. A high resistance rate was also observed to amikacin, trimethoprim/sulfamethoxazole, gentamicin and doxycyclin. Acinetobcater spp. are increasing day by day may be due to indiscriminate use of antibiotics in our hospitals. So, broad spectrum antibiotics should be used with caution and moreover controlled clinical trials of existing antimicrobian regimens and combinations are essential. The increasing prevalence of infections in ICU patients creates demand for strict screening and infection control strategies including transfer of infected or colonized patients to an isolated cubicle, cohort nursing ,hand hygiene sterilization & disinfection of equipment especially ventilators, education and awareness among health care workers to reduce frequency of nosocomial Acinetobcater baumannii infections.