الفهرس 
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Abstract
cute lymphoblastic leukemia (ALL) is a malignant disorder that originates from single B or T
lymphoid cells at an early
stage of proliferation with accumulation of blast cells in the marrow result in suppression of the
hematopoiesis and thereafter the presence of anemia, thrombocytopenia and neutropenia(Sherry,
2007andJalali et al., 2012).
Thrombo-embolism (TE) is a well recognized serious complication associated with ALL with potential
impact on overall outcome regarding mortality and morbidity and subsequently quality of life (Rau
et al., 2007and Jalali et al., 2012).
Acute lymphoblastic leukemia is the most common childhood malignancy as associated with various
coagulation abnormalities such as hemorrhage and thrombosis. The reported incidence of TE in
childhood ALL varies from 1.1% to 36.7% (Stefana et al., 2011). The wide variation in the reported
incidence of TE seems to be related to the definition of TE (symptomatic versus asymptomatic),
diagnostic method used for detection of TE, study design (prospective versus retrospective) and
treatment protocol (Ulrike et al., 2009).
The majority of symptomatic TE in children with ALL is venous and 5% of patients were reported to
have multiple sites involved. Thromboembolism of CNS occurs in 66% of cases, DVT