الفهرس 
Peptic UlcerOnly 14 pages are availabe for public view
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Abstract
Gastric ulcer is the common condition encountered
in clinical practice. Ulcers are produced because of the
inequity between aggressive and protective factors of the
mucosal layer.
For many years, aspirin had been recognized for its
therapeutic properties. Medications containing Salicylic
Acid had been used for a long time in treatment of
rheumatic diseases, wounds, menstrual pain and fever.
Aspirin can cause damage to the gastro-duodenal mucosa
via several mechanisms, including the topical irritant effect
of this drug on the epithelium, impairment of the barrier
properties of the mucosa, reduction of gastric mucosal
blood flow and interference with the repair of superficial
injury.
In recent years, stem cells in various tissues have
been a major focus of discussion in the scientific
community. Stem cells have been defined as cells with
unlimited capacity for self-renewal without senescence and
the ability to differentiate into one or more cell types in
vitro and in vivo. The possibility of using stem cells can be
improved, allowing better use of this important tool: as in
the repair of epithelial tissue after extensive lesions and even in research of mechanism of diseases, drug toxicology
screening, among other purposes.
Therefore, the present study tried to use a new
therapeutic modality to treat resistant gastric ulcer. So, the
current study was designed to evaluate the effect of bone
marrow mesenchymal stem cells (BM-MSCs) on gastric
mucosal damage induced by acetyl salicylic acid.
The experiment was conducted on 36 adult albino
rats with an average weight of 150 - 200 gm.
They were divided into four groups:
Group I: (Control group)
It included 12 rats, divided into two equal subgroups 6 rats
each:
Subgroup IA: Animals were given 1ml of 0.9%
physiological saline by intravenous injection (tail vein) in
an amount used as a solvent for of BM-MSCs.
Subgroup IB: Animals were given 1ml of 0.9%
physiological saline orally by intra-gastric tube in an
amount used as a solvent for of BM-MSCs.
In each rat of this group, bone marrow was collected
from both tibia and femur and BM-MSCs were cultured.