الفهرس 
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Abstract
This study aimed to measure vitamin D binding protein in children with type – one diabetes mellitus both in serum and urine, and to evaluate these levels in relation to the studied clinical , laboratory and radiological parameters .
This is a case_control study included children with a previously documented diagnosis of diabetes mellitus type 1 (on the basis of presence of anti_insulin antibodies and follow up in the out patient clinc for diabetes mellitus of children’s university hospital at Minia University) . The study carried out on 50 children aged 7-15 years ( 29 males (58%) and 21 females (42%) ) ; attending the out patient clinc for diabetes mellitus of children’s university hospital , Minia University during the period from August 2011 to August 2013.
The studied children were grouped into :
Group 1: 30 children with diabetes mellitus type 1.
Group II : 20 apparently healthy children as a control group.
All children were subjected to the following:
1- Full history taking.
2- Thorough physical examination.
3- Laboratory investigations included :
• Fasting and 2 hours postprandial blood glucose levels.
• Glycated hemoglobin. (HbA1c).
• Renal and liver function tests.
• Urinary albumin (microalbumin).
• Serum vitamin D binding protein.
• Urinary vitamin D binding protein.
4- Radiological skeletal survey (for diabetic children only).
The study showed that there were :
• No significant differences between diabetic children and controls as regard age , sex , residence or similar condition but there were significant differences between diabetic children and controls as regard family history and breast feeding .
• No significant differences between diabetic children and controls as regard weight, height ,head circumference or body mass index.
• Highly significant differences between diabetic children and controls as regard fasting blood sugar, 2 hours postprandial blood sugar and glycated hemoglobin.
• Highly significant difference between diabetic children and controls as regard hemoglobin .
• No significant differences between diabetic children and controls as regard white blood cells , platelets , urea , creatinin levels and liver enzymes ( aspartate aminotransferase and alanine aminotransferase).
• Highly significant difference between diabetic children and controls as regard microalbuminurea .
• No significant differences between diabetic children and controls as regard calcium , phosphorus or alkaline phosphatase.