الفهرس 
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Abstract
study was designed as a cross sectional descriptive study aiming to study the pattern of thyroid functional derangements in patients with metabolic syndrome. A total of 130 patients with metabolic syndrome were recruited into the study
An informed written consent was obtained from all patients. All of the studied patients were subjected to full clinical assessment and complete laboratory investigations was performed to evaluate thyroid function and lipid profile.
It was found that mean age among the studied patients was 57.5 years old. Most of the studied patients were in age group 55 – 65 years old (46.15%). More than half of the studied patients were females (67.69%).
Our results have shown that most of the studied patients have normal total cholesterol level (87.69%) while more about half of the studied patients have abnormal high LDL-cholesterol (42.31%).while about 58 of the studied patients have abnormal triglycerides (44.62%).
As regarding thyroid function tests, we found that 27.69% of the studied patients have elevated TSH levels while only 4.61% have elevated free T4 levels. Also most of studied patients have normal TSH and free T4 levels (70% and 94.62% respectively).
The current study has found that mean fasting blood sugar was 177.8 mg/dl and that most of the studied patients have elevated fasting blood sugar (83.1%). According to HOMA-IR estimation, only one patient was found to have levels lower than 1.73 and that 99.2% of the studied patients were found to have insulin resistance.
Assessment of presence of thyroid dysfunction has shown that 26.15% of the studied patients have subclinical hypothyroidism.
There was no significant difference between patients with subclinical hypothyroidism and patients without subclinical hypothyroidism as regard age and sex.
Patients with subclinical hypothyroidism were found to have higher prevalence of abnormal triglycerides and HDL-cholesterol levels.
Although all patients had abnormal waist circumference and abnormal waist/hip ratio as presented previously in table 4, patients with subclinical hypothyroidism were found to still have higher values of waist circumference and wait/hip ratio.
There was no statistically significant difference between patients with subclinical hypothyroidism and patients without subclinical hypothyroidism as regarding HOMA-IR. Also that there was no significant correlation between HOMA-IR and neither free T4 and TSH whether in all patients or in each group of patients according to presence of subclinical hypothyroidism.
TSH was significantly correlated with triglycerides (weak positive correlation) and HDL (weak negative correlation). There was significant strong positive correlation between TSH and obesity parameters (waist circumference and waist/hip ratio). As regarding Free T4, it has significant correlation with fasting insulin (negative correlation), waist circumference and waist hip ratio (negative correlation.
In conclusion, subclinical hypothyroidism is prevalent thyroid disorder among patients with metabolic syndrome. Thyroid profile parameters especially TSH is significantly associated with metabolic syndrome components particularly obesity indicators.