الفهرس | Only 14 pages are availabe for public view |
Abstract The importance of studying Ps.aeruginosa microbes was attributed to the opportunistic nature of this bacterium, it also represent one of the most dangerous bacteria that causes nosocomial infection, as well as the high capability of this microorganism to acquire resistance against the different classes of antimicrobial chemotherapeutics and disinfectants. The current study aimed to find the correlation between reduced susceptibility to disinfectants and multidrug resistance among clinical isolates of Pseudomonas aeruginosa. Two hundred and forty specimens were collected from patients with various clinical cases including burn, wound, UTI, blood, otitis media, and respiratory tract infection samples from the Mansoura University Hospitals. The specimens were processed and yielded 104 non duplicate isolates that were identified as Ps.aeruginosa based mainly on their growth on cetrimide agar, oxidase test, motility test, pyocyanin pigment production and growth at 42 ᵒC. The susceptibility of Ps.aeruginosa isolates to different members of antipseudomonal drugs were determined by agar disk diffusion method. The isolates showed high sensitivity to piperacillin (79.8%), imipenem (78.84%), amikacin (73%) and gentamicin (69.23%). Meanwhile these isolates showed high resistance to sulfamethoxazole/trimethoprim (56.73%) and carbenicillin (100%). Out of 104 isolates, 36 were classified as MDR, being resistant to 3 groups or more of antimicrobial chemotherapeutic agents. |