الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Although antibiotics treatment of salmonellosis is consider an effective solution against invasive nontyphoidal Salmonella (iNTS) disease, but the increasing frequency of multidrug-resistant clinical isolates is concerning and hampers the effectiveness of this treatment. Therefore vaccination is the most promising strategy for the control of iNTS disease. As a result of increasing the pathogenicity of many infectious agents, it was an urgent need to make vaccines more effective and that by adding substances what’s called immune-modulators to accelerate, prolongs, or enhances antigen-specific immune responses when used in combination with specific vaccine antigens.
Using of thymol in form of adjuvant induce the immune response, also as it has antibacterial effect, it improve the performance of tested rabbits in comparing with using of CFA as adjuvant.
In the present work a total of 25 rabbits were used and randomly divided into 4 main groups, three groups were vaccinated with heat killed Salmonella Typhimurium vaccine either alone, or combined with complete Freund′s adjuvant, or thymol oil extracted from Thymus vulgaris and the fourth group served as control. Rabbits in the first three groups were received the S. Typhimurium vaccine i.m. during the whole course of the experiment while control group, they received PBS. Blood was collected weekly in the first three weeks of the experiment, and then the rabbits were received booster dose at the end of the third week. Blood samples were collected for sera separation