الفهرس 
Psoriatic ArthritisOnly 14 pages are availabe for public view
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Abstract
Psoriatic arthritis (PsA) is an inflammatory arthritis that is associated with skin psoriasis. It can affect the joints and surrounding structures such as the tendons and ligaments, specifically as dactylitis and enthesitis.
Several studies demonstrated that anti-mutated citrullinated vimentin (anti-MCV) antibodies have the same specificity as anti-CCP antibodies, but with better sensitivity in diagnosis of RA.
Diagnosing PsA is necessarily complex and true laboratory diagnostic markers are lacking.
Because of the several clinical similarities between PsA and RA, and the fact that the anti-MCVs are highly sensitive markers in RA, the current study was performed to investigate the presence of anti-MCVs in psoriatic arthritis patients and psoriasis vulgaris patients without arthritis and its potential correlation with clinical and laboratory parameters.
The study included 25 psoriatic arthritis patients fulfilling the CASPAR classification criteria for psoriatic arthritis, 25 psoriatic patients without arthritis (psoriasis vulgaris PsO) and 25 rheumatoid arthritis (RA) patients fulfilling American College of Rheumatology (ACR) criteria for RA 1987 as a control group.
The ESR, CRP and RF were found to be higher in RA group than in PsA group and PsO group with a statistically significant difference.
The number of tender joints is higher in RA group in comparison with the PsA group with no significant difference between the 2 groups while the number of swollen joints is significantly higher in RA group.
The DAS28 score either ESR or CRP were higher in RA group with highly significant difference compared to PsA group but it did not correlate with anti-MCV titres.
The difference in PASI scores in PsA group and PsO group were insignificant and did not correlate with anti-MCV titres.
The anti-MCV level is significantly lower in PsO group in comparison with the PsA group and the RA group.
Anti-MCV levels were found to be positive in 60% of PsA group, 28% of PsO group and 64% of RA group.
There is a significant correlation between anti-MCV levels and RF levels.
The sensitivity of anti-MCV was found to be 84% and the specificity was 40%.