الفهرس 
Myocardial InfarctionOnly 14 pages are availabe for public view
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Abstract
Aims: The present study was conducted to investigate and compare the effects of ivabradine and bisoprolol on experimentally induced ischemia-reperfusion in rats.
Methods and Results: A new multi-vessel ligation method for 30 minutes followed by 90 minutes of reperfusion was used as a procedure to induce ischemia-reperfusion in albino Wister rats. All rats were subjected to continuous ECG and real-time PCR for detection of apoptotic factor, BAX gene in hearts. Ivabradine and bisoprolol led to significant reduction in heart rate and BAX gene expression to the same extent but ivabradine produced more significant reduction in BAX gene expression on RCA occlusion. Bisoprolol led to insignificant change in QT and QT intervals on LM occlusion, significant reduction on LAD occlusion and significant prolongation on RCA occlusion while ivabradine led to insignificant changes in these intervals. Bisoprolol led to significant decrease in arrhythmia score while ivabradine did not.
Conclusions: Whatever the drug used, the more the heart rate reduction, the less the myocardial cell damage. Actions of ivabradine and bisoprolol differ if the culprit artery changed, hence, the importance of multi-vessel ligation method in myocardial infarction assessment. Ivabradine was superior to bisoprolol as a cardio-protective drug on myocardial infarction caused by RCA occlusion and was non-inferior on LM and LAD occlusion. Bisoprolol was superior to ivabradine as an anti-arrhythmic drug. Bisoprolol led to differential changes (according to the culprit artery) while ivabradine led to insignificant changes on QT and QT intervals.
Keywords: Ivabradine; Bisoprolol; Myocardial infarction; Multi vessel method; BAX gene.