الفهرس 
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Abstract
Thyroid gland is an endocrine organ situated in the lower part of the front of the neck. The main function of the thyroid gland is to secrete a sufficient amount of thyroid hormones, tetraiodothyronine (T4) and triiodothyronine (T3). Thyroid hormones promote normal growth and development and regulate a number of homeostatic and metabolic processes. Liver Cirrhosis represents the final common histological pathway for a wide variety of chronic liver diseases. Cirrhosis is defined histologically as a diffuse hepatic process characterized by fibrosis and the conversion of normal liver architecture into structurally abnormal nodules. In developing countries viral hepatitis is the leading cause of cirrhosis. This study was conducted on 69 patients and 20 healthy subjects as control. All subjects were selected from inpatient and outpatients liver clinic in Menofia University and Shebein El-kom Fever Hospital to assess the levels of thyroid hormones and TSH in hepatitis B and hepatitis C related liver cirrhosis and their relation to severity to liver cirrhosis. All subjects had been divided in to 3 groups: Group1:39patients with chronic hepatitis C related liver cirrhosis Group11:30 patients with chronic hepatitis B related liver cirrhosis. Group 111:20 healthy subject’s age and sex matched as control group. Statistical analysis of the results of the present study revealed the following points: • No statistically significant difference between the studied groups as regard age and sex distribution. • No significant difference between the studied groups as regard Hemoglobin, TLC, platelet count, BMI, kidney function tests. • Highly significant negative correlation between Child classification and Free T3 (p value <0.001) but no statistical difference between child classification andFT4 and TSH (P value >0.05). • No significant statistical difference between hepatitis B and hepatitis C as regard thyroid function (P value >0.05). • Highly significant positive correlation between free T3 and serum albumin(p value <0.001) and highly significant negative correlation between free T3 ,bilirubin and PT (p value <0.001). • As the conversion of T4 to T3 in extrathyroidal tissue occurs through a rapidly equilibrating pool via the D1 enzyme system and a slowly equilibrating pool via D2 system. The type 1 deiodinase is mainly found in liver and kidney and accounts for approximately 30% to 40% of extra thyroidal production of Free T3.The type 2 deiodinase is found in the pituitary, CNS, the skeletal muscle and contributes about 60% to70% of the extra thyroidal production of Free T3. So we probably suggest that decrease Free T3 is due to affected type D1 enzyme system in cirrhotic patients.