الفهرس 
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Abstract
The present study was conducted to compare histologically the bone regeneration capacity of a locally prepared injectable Bioactive glass composite (PVA-BG) and another Bioactive Glass product (Biogran®) as a bone substitute in surgically induced mandibular bone defects in dogs.
The study was conducted on 12 healthy adult mongrel dogs. Artificial bony defects were created in each side of the mandible by the aid of trephine burs, the defects of the right side were filled with PVA-BG composite(Group A) while the left side defects were filled with Biogran®(Group B). For all dogs post-operative prophylactic antibiotic was given and soft diet was administrated.
Sacrification was done at 2,6 and 12 weeks intervals from the initial surgery; four dogs for each interval. Histological examination was performed for each specimen using H&E and Trichrome stains to evaluate the cellular changes in bone-graft interface and to monitor the new bone formation process.
The results revealed that both materials showed osteoconductive and osseointergration properties. Both materials supported bone formation, and integration with host bone was obvious with no signs of material rejection. The rate of bone formation was found to be slightly faster for Group B at the early periods. However, at 12 weeks both groups developed lamellar bone with well defined haversian system.
The rate of materials degradation was found to be slightly faster at Group B with almost complete resorption after 12 weeks in most sites. On the other hand, Group A showed very small remnants of material after 12 weeks.