الفهرس 
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Abstract
Involvement of the furcations of multirooted teeth represents a challenge in the treatment of periodontal disease, both from a prognostic perspective and from the perspective of therapeutic measures.
The current investigation was conducted to evaluate, histologically, the regenerative potential of PTG® in the management of advanced grade II furcation defects and to compare it with conventional therapy using an alloplastic material, β-TCP.
A total number of five adult systemically healthy mongrel dogs (Canis familaris) were included in the current study. Grade II critical –sized furcation defects were surgically created with respect to lower premolar teeth. In all five dogs, the mandibular third (P3) and fourth (P4) premolars on the left quadrants received PTG® and alloplastic material, respectively. They were then covered by a collagen membrane. On the right quadrants a single defect was created in the interradicular bone of the mandibular third premolar (P3) without the application of any regenerative materials, to serve as a negative control side. Three dogs were sacrificed one month after surgery, and the other two were sacrified after two months.
The jaws were sectioned and the resultant tissue blocks of the experimental teeth were prepared to be examined histologically. Serial sections were then obtained and stained using hematoxylin and eosin and trichrome stains.
Descriptive histological results showed a distinctive amount of vascularization and regenerative potential in PTG® group regarding bone maturity, cementum formation and periodontal ligament fibers.
Moreover, colorimetric analysis revealed a statistically significant increase in mean bone density levels of PTG group as compared to positive control group (group II) at two months value (P<0.05), while at one month There was an increase in mean bone density levels between PTG group and positive control group but it was not statistically significant (P>0.05).
When comparing the mean bone density levels of PTG group and negative control group, PTG group value showed a statistically significant increase in mean bone density when compared to negative control group value at one month (P<0.05), as well as at two months (P<0.05).
On the other hand, at one month there was an increase in mean bone density levels in β-TCP group as compared to negative control group, however, it was not statistically significant (P>0.05). While there was a statistically significant increase in β-TCP value (p<0.05) at two months as compared to negative control group value.