الفهرس 
Anatomical and histological aspects of the corneaOnly 14 pages are availabe for public view
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Abstract
The cornea is a transparent non-vascular tissue that is exposed to the external environment. It protects the interior ocular tissues by providing a competitive barrier between fluid loss and penetration of pathogen and it is considered the first line of defense against many aggressors such as bacteria, virus, fungi, allergens, contact lens wear, photorefractive surgery, or preservatives which can be responsible for corneal epithelial cell disruption.
Benzalkonium chloride (BAC) is a quaternary ammonium compound which is the most common preservative used in ophthalmic preparations to treat glaucoma and ocular surface diseases. It is most often used at a concentration of 0.01% (range, 0.005-0.02%) in topical multi-dose solutions. However, BAC has been shown to be highly toxic both in vitro and in vivo due to a stimulatory effect on epithelial cell death.
Sodium hyaluronate is a viscoelastic substance which does not induce inflammation. It has a mucinomimetic properties and it has been used as a good corneal protectant in both humans and animal.
This work was designed to focus on the histological and immunohistochemical changes induced by Benzalkonium chloride on the cornea of adult albino rats and the possible protective role of Sodium hyaluronate.