الفهرس 
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Abstract
The nitrogen containing organic compounds are of immense importance. The thesis is devoted to the development of new methods for the analysis of amino containing compounds, namely: ethamsylate (EST), lacidipine (LCP), esomeprazole magnesium trihydrate (EMZ), Pantoprazole sodium sesquihydrate (PRZ), propafenone hydrochloride (POP) and domperidone (DMO) in pharmaceutical preparations and/or biological fluids. This thesis comprises six main parts. The first one included a general introduction about amino containing compounds and their importance. Two spectrophotometric methods were developed for determination of EST in pure form and pharmaceutical dosage forms depending on the aromatic nucleophilic substitution reaction. The method was extended to investigate EST in the presence of its degradation product.
Moreover, spectrofluorimetric method was investigated for determination of LCP in pure form and tablets. The methods were further applied to content uniformity and human plasma.A sensitive and specific micellar spectrofluorimetric method was also developed for determination of EMZ and PRZ in their dosage forms. The method was further extended to the in-vitro determination of both drugs in spiked human plasma. Additionally, simple and highly sensitive stability-indicating high-performance liquid chromatographic method with UV-detection was developed for determination of POP in its tablets. The method was extended to investigate the inherent stabilities of POP after exposure to different stress degradation. Finally, ratio derivative spectrophotometry was developed for the simultaneous analysis of DMO and EMZ or PRZ in their co-formulated tablet. All the results were statistically analyzed and compared with those obtained by comparison methods.