الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
The present study aimed to investigate and evaluate the protective role of curcumin on sodium arsenite (As) induce toxicity in pregnant mice and their newborns. Four groups, each of which included 20 pregnant mice were treated as follows: The 1st group (control) was orally administrated with corn oil every other day at a dose of (200mg/kg b.w.) from day 8 of gestation till birth. The 2nd group was orally administrated with curcumin dissolved in corn oil at a dose of (200mg/kg b.w.) every other day from day 8 of gestation till birth. The 3rd group was injected intraperitoneally by a single dose of sodium arsenite (12mg/kg b.w.) dissolved in saline solution on day 8 of gestation, after which they were kept till birth. The 4th group was received a single dose of sodium arsenite (12mg/kg b.w.) by intraperitoneal injection. Then they were orally administrated with curcumin at a dose of (200mg/kg b.w.) every other day from day 8 of gestation till birth. Ten pregnant animals from each studied groups were sacrificed at 18th day of gestation and the incidences of pregnancy outcome were recorded. The remaining pregnant mice were kept till parturition. The results showed that As induced elevation in the rate of abortion as well as fetal resorption, mortality and malformation, significant reduction of body weight, body size as well as crown-rump length and general retardation of skeletal development in delivered newborns. Moreover, As caused histological degeneration to hepatic tissue in both mothers and newborns. Also, it increased production of inflammatory cytokines as IL-5 and IFN-γ. The results indicated that orally administration of As treated pregnant mice with curcumin reduced the high incidence of resorption, the rate of dead fetuses, fetal growth retardation, incidence of malformation and the defects in the skeletal development in newborn .It has efficiency improve the adverse effect of sodium arsenite on the hepatic and renal tissue in both mothers and newborns. Also, curcumin inhibited the inflammatory cytokines (IL-5 & IFN-γ).