الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
Hereditary C1q deficiency is strongly related to SLE but there are very few and inconsistent studies exploring the single nucleotide polymorphisms (SNPs) of the C1q gene cluster in relation to the pathogenesis of SLE. In the present study we evaluated the possible association of gene variants in complement C1q gene cluster with susceptibility to lupus nephritis in Egyptian children, comparasion with previously SLE SNPs in other populations.The study conducted on 50 patients with juvenile lupus in addition to 50 of age and sex matched healthy children as a control. C1q gene polymorphism typing carried out for both groups by molecular biology technique.In the present study, there was significant decrease in total leucocytic and platelet counts, hemoglobin concentration, serum C3 concentration and significant increase in serum creatinine in the SLE patients when compared to control subjects. In the same time, Comparison of laboratory data in patients with LN and those without revealed significant difference in platelet count,increased of proteinuria and hematuria.C1qA gene AA genotype is significantly increased in studied juvenile SLE patients when compared to healthy control subjects, with high risk to develop SLE and no significant associations were found between C1qA (genotypes and alleles) and risk of LN development within studied pSLE patients.