الفهرس 
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Abstract
This study aimed to : Diagnosis and differentiation of product of conception specimens including complete hydatiform mole (CHM), partial hydatiform mole (PHM) and hydropic abortion (HA) is important. CHM and PHM carry a risk for progression to persistent gestational trophoblastic disease (PGTD). Histopathological examination is the main tool for diagnosis of POC specimens, however, histopathological similarities are observed between these cases especially in early gestational age. The difficult cases may require additional techniques such as molecular methods or immunohistochemical stain for p57Kip2 gene by the trophoblastic cells. The p57Kip2 gene (CDKN1C) is a paternally imprinted gene expressed only by the maternal allele. It can identify CHM by the lack of its expression and distinguish CHM from PHM and non molar HA, but can’t distinguish PHM from non molar specimens, both are positive. Aim : Differentiate between cases of molar and non molar cases on the basis of histopathological criteria and detect the role of p57Kip2 immunohistochemical in differentiation. Methods : Sixty five blocks of formalin fixed paraffin-embedded POC specimens were re-cut at 5 microns thickness sections and stained with haematoxylin and eosin stain and examined for the different histopathological criteria. The slides stained for p57Kip2 to identify CHM. Results : Many histopathological criteria were found to be significant in differentiation between CHM and PHM cases : Villous shape and outline, villous trophoblast hyperplasia and atypia at extravillous trophoblast. p57Kip2 immunohistochemistry was statistically significant in diagnosis of CHM and differentiation it from PHM and non molar cases. Conclusion : Histopathological diagnosis of molar pregnancy remains problematic especially in early gestational age. Attention should be paid to the fact that diagnosis of molar pregnancy in first trimester shouldn’t be stated except after constellation of specific histopathological criteria in order not to miss the diagnosis of CHM. This study also concluded that p57Kip2 can be used as a useful diagnostic tool for diagnosis and classification of HM cases.