الفهرس 
Diabetes MellitusOnly 14 pages are availabe for public view
 |  | from | 227 |  |  |
| | | from | 227 | | |
Abstract
Exendin-4 is a peptide secreted in the saliva of the Gila monster, it binds to and activates the glucagon-like peptide-1 (GLP-1) receptor and shares many glucoregulatory properties with native GLP-1. The present work was performed to study the effect of exedin-4 on some liver functions impaired by renal ischemia-reperfusion in normal and diabetic male rats. Sixty male Wistar rats were used in this study; these animals were divided into six equal groups (ten rats in each group). Group I; Control sham operated normal rats (Sh. Op. ND. group): Injected by saline in a dose of 10 µl, subcutaneous, twice daily for two weeks, then sham operation was done by opening and closure of the abdomen. Group II; Control sham operated diabetic rats (Sh. Op. DM. group): Diabetes was induced by a single intraperitoneal injection of streptozotocin in a dose of 60mg/kg. Then, the rats were injected by saline in a dose of 10 µl, subcutaneous, twice daily for two weeks then sham operation was done.