الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Biofilms are increasingly recognized as playing an etiological role in CRS. Bacteria in biofilms are difficult to culture and largely resistant to host defence systems and antimicrobial therapy There have been several reports regarding the presence of biofilms in surgical specimens obtained from patients with CRS.
The aim of the current study was to identify the presence of the bacterial biofilms on surface mucosal specimens of nasal polyps in chronic rhino-sinusitis patients using both SEM and H&E staining protocol and to evaluate the relationship between the presence of bacterial biofilm and the severity of chronic polypoidal rhinosinusitis both subjectively & objectively.
The study was performed on 40 patients who were attending Otorhinolaryngeology clinic (at the main hospital of university of Alexandria) 30 cases suffering from CRS wNP and the other 10 cases were scheduled for septoplasty. All patients were assessed by preoperative Lund-McKay’s score, Johnson’s score and Visual Analogue Scale.
Polyps were taken intraoperative from the CRS patients and tissue specimens from the anterior end of the inferior turbinate were taken from the control group and all samples were sent to be assessed by SEM and H&E stain and to be cultured for bacteriological assessment.
The study results showed significant presence of bacterial biofilm in cases of chronic polypoidal rhinosinusitis using SEM, but didn’t show significant relation between the presence of biofilm and severity of the disease, and also the results of H&E study had a high sensitivity and specificity in relation to SEM.