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Abstract
Endothelial Microparticles (EMPs) are small vesicles shed from activated or apoptotic endothelial cells and involved in cellular cross-talk. Whether EMP immunophenotypes vary according to stimulus in Diabetes Mellitus (DM) is not known. We studied the circulating EMPs in patients with Diabetes Mellitus type 2,with and
without complications(cardio vascular).
EMPs were analyzed by flow cytometry. The absolute median number of EMPs (EMPs/μL) specific for CD31 and CD62E
and was significantly increased in the DM population. The ratio of
CD62E/CD31 EMP populations reflected an apoptotic process Circulating CD31+andCD62EEMPs were significantly elevated in patients with DM. Additionally, studies demonstrate that, EMPs correlate in vivo with indices ofEC dysfunction, the presence of
coronary artery disease and with the complications of Diabetes
Mellitus type 2 (DM). DM is a major risk factor for cardiovascular morbidity and mortality, and the proportion of cardiovascular disease attributable to DM has increased over the past 50 years It is well established that endothelial dysfunction and inflammation are key features of DM and are independent of other cardiovascular risk factors. The aim of this work was to study the endothelial microparticles in patients with type 2 Diabetes mellitus and its relation to disease complication.