الفهرس 
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Clinical Manifestations And Diagnosis OfOnly 14 pages are availabe for public view
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Abstract
Aim of the work: Evaluate retrospectively epidemiologic and clinico-pathological characteristics as related to prognosis of colorectal cancer patients diagnosed and/or treated at NCI, Cairo between 2007-2008.<Patient and methods: We retrospectively evaluate epidemiologic, clinic-pathologic characteristics, prognostic factors affecting disease free survival and time to disease progression in a cohort of 496 patients with colorectal cancer diagnosed and/or treated at NCI in the period from January 2007 till December 2008.<Results: Median age at diagnosis was 47.5 years and range from 13 to 83 years. Age of colon cancer patients was 48.36±14.85 years and of rectal cancer was a 46.90±14.58 years. Bleeding per rectum is the commonest presentation (37%) and most of patients have resectable tumors (51.4%).Rectal tumors constituted 55.6% of cases, and colon 44.4%. Pathology was available for 462 cases, of them 76.6% was non-mucin secreting adenocarcinomas, moderately differentiated (grade II) CRC was the most common type accounting for 78.5% of cases. T3 was the most common accounting for (49.0%), N0 was the most common N stage accounting for 48.9% of cases. For TNM stage, stage III was the most common accounting for 29.0% of cases and those metastatic at presentation, M1, represents 23.0%. Median DFS of patients with colorectal cancer at NCI 2007-2008, was 85.42 months. On univariate analysis gross site, N stage and TNM staging were significantly associated with DFS. Median PFS was 27.86 months. Diabetes mellitus, M stage and chemotherapy treatment for metastatic or locally advanced disease were significantly associated with PFS Conclusion: N stage was the only independent prognostic factor found to affect DFS. M stage was the only independent prognostic factor found to affect PFS Key words: colorectal cancer- prognosis-disease free survival- progression free.