الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Many breast lesions represent diagnostic difficulty as microglandular adenosis, sclerosing adenosis, radial scar and different papillary lesions. Histopathological examination is the main tool for diagnosis of such lesions specimens, however, histopathological similarities are observed between these cases. The difficult cases may require additional techniques such as immunohistochemical stain for p63 gene. The p63 gene expressed mainly by myoepithelial cells. It can distinguish benign lesions from non invasive and invasive carcinoma specimens. Aim : Differentiate between cases of non neoplastic breast lesions and carcinoma on the basis of histopathological criteria and detect the role of p63 immunohistochemical in differentiation. Methods : 50 blocks of formalin fixed paraffin-embedded different breast lesions specimens were re-cut at 5 microns thickness sections and stained with haematoxylin and eosin stain and examined for the different histopathological criteria. The slides stained for p63. Results : Many histopathological criteria were found to be significant in differentiation between non neoplastic breast lesions and carcinoma. P63 immunohistochemistry was significant in diagnosis of non neoplastic breast lesions and differentiation of these lesions from invasive carcinoma cases. Conclusion : Histopathological diagnosis of non neoplastic breast lesions specimens that simulate carcinoma remains problematic issue. Identification of myoepithelial cells is important to confirm diagnosis. This study also concluded that p63 can be used as a useful diagnostic tool for diagnosis and classification of non neoplastic breast lesions cases. It was of great value in diagnosis of cases that had equivocal morphology by histopathological examination.