الفهرس 
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Abstract
Nephrotic syndrome (NS) is a common chronic disease in children. It
is a clinicolaboratory syndrome, characterized by proteinuria
,hypoalbuminemia, edema, and hyperlipidemia.
This study done in outpatient nephrology and audiology clinics at
Beni-Suef University hospital at a period from 3-2013 to 5-2014. This
study included 60 nephrotic patients.
All patients subjected to:-
1-Informed consent obtained from the parents
2-Full history taking
3-Full clinical examination
4- Biochemical investigations performed during the follow up of the
patients after the initial improvement in the form of serum albumin ,
cholesterol, sodium, potassium, calcium, phosphorus and magnesium.
5- Histological diagnosis of nephrotic syndrome (renal biopsy) if
present.
6-Hearing assessement through tympanometry, audiometry, ABR and
OAE:-
These tests were ordered to evaluate the affection of the hearing in NS
and to monitor for the potentially ototoxic effects of certain drugs or
chemicals used in treatment of nephrotic syndrome and also the effect of
electrolytes disturbance on hearing so it should be considered when
following up children with nephrotic syndrome.
7- Evaluation of the school performance to detect the effect of hearing
impairment on it.
60 patients of both sex and at the age range 7-16 years old with a mean
of 10.4 ± 2.8 were included in the study, they were collected from
outpatient nephrology clinic at Beni-Suef University. Hearing
assessement was then performed for all nephrotic children.
In this study 9 cases on cyclosporine had cochlear
dysfunction, they represented 75% from patients on cyclosporine therapy.
Also one case on MMF had SNHL, it represented 33.3% from patients on
MMF therapy.
There was no relation between hearing impairment and the
following parameters (school performance, steroid therapy, endoxan
therapy, type of nephrotic syndrome, hypocalciumia or hypomagnesimia).
The only significant values were between cyclosporine and
OAE and between MMF and audiogram which detected that the hearing
affected by some cytotoxic drugs.