الفهرس 
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Abstract
Determinations of neopterin levels reflect the stage of activation of the cellular immune system which is of importance in the pathogenesis and progression of various diseases.
Increased neopterin concentrations in body-fluids, such as serum or urine, are connected with diseases linked with cellular immune reaction, Therefore it is of interest for laboratory diagnosis to measure the degree
of activation of the human immune system. This is possible in an easy but specific way by the determination of neopterin concentrations.
The results were statistically analyzed and we found that :
Both patients group and control group were similar as regarding
general characteristic , 40% of patients are females 60% are males.
All patients have high serum neopterin level,with higher levels in non-splenectomized group.
By analysis of the laboratory findings that may contribute
to the elevated serum neopterin level. We found that of all the studied factors only low Hb% and hematochrite in non-splenectomized group with p.value = 0.001, p.value ≥0.001 respectively were independent predictors of elevated serum neopterin levels with significant positive correlation.
There was statistically significant difference in serum neopterin level Between the two studied subgroups of patients of our study and when these studied groups compared with the control group serum neopterin level was elevated in each subgroup with significant difference .
Also by the subgroups analysis we found that there’s statistically significant difference in serum ferritin with higher levels reported in splenectomized group.
However this difference was not translated into a significant difference in relation between the serum neopterin level and serum ferritin level.
Also by the subgroups analysis , the reticulocytic count showed statistically significant different (P-value =0.042) Being higher in splenectomized group (5.6±2.0 % ).